2007, Cilt 21, Sayı 1, Sayfa(lar) 027-031 |
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EVALUATION OF METHICILLIN RESISTANCE AND SUSCEPTIBILITY TO VARIOUS ANTIMICROBIAL AGENTS OF STAPHYLOCOCCUS AUREUS STRAINS ISOLATED IN CLINICAL SPECIMENS |
Fahriye EKŞİ, İclal BALCI, Efgan D. GAYYURHAN, Goncanur ÇEKEM |
Gaziantep Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Gaziantep |
Keywords: Staphylococcus aureus, MRSA, MSSA, antibiotic susceptibility |
The aim of this study was to evaluate the susceptibility of Staphylococcus aureus strains isolated in various clinical specimens to
methicillin and other various antimicrobials suggested for treatment. In this study, 116 S. aureus strains isolated in various clinical
specimens were evaluated and their antimicrobial susceptibility tests were performed using disc diffusion method according to the
suggestions of Clinical and Laboratory Standards Institute (CLSI). In order to test the susceptibility to methicillin, Mueller-Hinton
agar containing 4% NaCl and 1µg oxacillin discs were used. Among 116 S. aureus strains evaluated, 71 (61.2%) were found to be
resistant to methicillin (MRSA) and 45 (38.8%) were found to be susceptible to methicillin (MSSA). According to the susceptibility
results, it was observed that MRSA strains were resistant 85.9% to ciprofloxacine, 73.2% to rifampin, 73.2% to gentamycin, and
59.2% to azithromycin, but all strains were susceptible to teicoplanine and vancomycin. There was a high rate (91.1%) of
penicillin resistance for MSSA strains, and the most effective antibiotics were found to be meropenem, sefotaxim and ciprofloxacin
for these isolates. As result, the resistance pattern of MRSA strains is remarkable, but on the other hand, it is good to see that there
was no resistance to vancomycine and teicoplanin in the present study.
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