2007, Cilt 21, Sayı 1, Sayfa(lar) 033-038 |
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THE PRESENCE OF EXTENDED-SPECTRUM BETA-LACTAMASE AND SENSITIVITY TO ANTIBIOTICS IN CLINICAL KLEBSIELLA ISOLATES |
Ferhat IŞIK, Uğur ARSLAN, İnci TUNCER |
Selçuk Üniversitesi Meram Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Konya |
Keywords: Klebsiella, extended spectrum beta-lactamase, antibiotic resistance |
The purpose of the present study was to investigate the presence of extended spectrum beta-lactamase (GSBL) in the Klebsiella
spp. isolated from clinical samples in the Meram Medical Faculty Hospital, Konya and also to determine the sensitivities of the
positive and negative strains of GSBL to some antibiotics. After species determination of 154 Klebsiella strains the presence of
GSBL was determined by using phenotypic check method. Antibiotic sensitivities of the GSBL positive and negative strains were
determined using disc diffusion method (following with CLSI standards). The identified species were as follows: 115 (74.7%)
K. pneumoniae, 17 (11%) K. ornithinolytica, 16 (10.4%) K. oxytoca, 4 (2.6%) K. planticola and 2 (1.3%) K. terrigena strains. Of the
154 Klebsiella spp. 87 (56.5%) had the capacity to produce GSBL. In GSBL positive strains the rates of antibiotic resistance were as
fallows: 18.4% to piperacilin-tazobactam, 26.4% to amikacin, 53% to ciprofloxacine, 54% to netilmicine, 62% to
trimethoprim/sulfamethoxazole, 69% to gentamicin, 71.3% to tobramicin and 92% to amoxicillin-clavulanate. For the GSBL negative
strains these rates were %4.5, %7.5, %12, %15, %23.8, %25.4, %25.4 and %53.7, respectively. There was no imipenem resistance
in GSBL positive and negative strains. In conclusion, the rates of antibiotic resistance were significantly higher in GSBL positive
strains then in GSBL negative ones (p<0.05).
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