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2007, Cilt 21, Sayı 1, Sayfa(lar) 033-038
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THE PRESENCE OF EXTENDED-SPECTRUM BETA-LACTAMASE AND SENSITIVITY TO ANTIBIOTICS IN CLINICAL KLEBSIELLA ISOLATES
Ferhat IŞIK, Uğur ARSLAN, İnci TUNCER
Selçuk Üniversitesi Meram Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Konya
Keywords: Klebsiella, extended spectrum beta-lactamase, antibiotic resistance

The purpose of the present study was to investigate the presence of extended spectrum beta-lactamase (GSBL) in the Klebsiella spp. isolated from clinical samples in the Meram Medical Faculty Hospital, Konya and also to determine the sensitivities of the positive and negative strains of GSBL to some antibiotics. After species determination of 154 Klebsiella strains the presence of GSBL was determined by using phenotypic check method. Antibiotic sensitivities of the GSBL positive and negative strains were determined using disc diffusion method (following with CLSI standards). The identified species were as follows: 115 (74.7%) K. pneumoniae, 17 (11%) K. ornithinolytica, 16 (10.4%) K. oxytoca, 4 (2.6%) K. planticola and 2 (1.3%) K. terrigena strains. Of the 154 Klebsiella spp. 87 (56.5%) had the capacity to produce GSBL. In GSBL positive strains the rates of antibiotic resistance were as fallows: 18.4% to piperacilin-tazobactam, 26.4% to amikacin, 53% to ciprofloxacine, 54% to netilmicine, 62% to trimethoprim/sulfamethoxazole, 69% to gentamicin, 71.3% to tobramicin and 92% to amoxicillin-clavulanate. For the GSBL negative strains these rates were %4.5, %7.5, %12, %15, %23.8, %25.4, %25.4 and %53.7, respectively. There was no imipenem resistance in GSBL positive and negative strains. In conclusion, the rates of antibiotic resistance were significantly higher in GSBL positive strains then in GSBL negative ones (p<0.05).

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