2008, Cilt 22, Sayı 4, Sayfa(lar) 241-249 |
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VIRAL ETIOLOGY IN OBESITY |
Pelin TUNCER, Kadir YEŞİLBAĞ |
Uludağ Üniversitesi Veteriner Fakültesi, Mikrobiyoloji Anabilim Dalı, Viroloji Bilim Dalı, Bursa |
Keywords: Obesity, virus, SMAM-1, Adenovirus 36, leptin |
Currently obesity is one of the important health problems around the world. It is accepted that enviromental, genetic, neuronal and
endocrinologic factors take place in the etiology of obesity. Changing the dietery regimes or living style does not always solve the
problem. Also realising the rapid spread of obesity like infectious diseases connote that the pathogens may have a role in the
etiology of obesity. Studies on that basis have shown that 8 viruses can be stated in the etiology of obesity. Among them 5 animal
viruses, namely; canine distemper virus, Rouss-associated virus type 7, Borna disease virus, scrapie agent and SMAM-1 virus have
been described, four of which have effect on central nervous system while SMAM-1 acts directly affects adipocytes and also
concerns human obesity. The remaining 3 viruses are human viruses, namely; Adenovirus 36 (Ad-36), Ad-37 and Ad-5. They affect
directly on adipocytes. Although Ad-37 and Ad-5 cause obesity only in animals, Ad-36 causes obesity not only in animals but also in
humans. These pathogens lead to accumulation of triglyceride and differention of the pre-adipocytes into mature adipocytes.
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