Crimean–Congo Hemorrhagic Fever (C-CHF) is generally a severe viral disease affecting multiple organ systems. In this study, we report eight cases admitted to our hospital from the Mid-Eastern Anatolia Region of Turkey and were diagnosed C-CHF. Three cases were from Giresun, two from Ordu, one from Kastamonu, one from Gümüshane and one from Sivas. Six cases had history of tick bite or tick contact. All cases had high fever. Other clinical features were as follows: weakness (six cases), myalgia (six cases), headache (three cases), petechial rash (three cases), gingival bleeding (one case) and epistaxis (one case). Laboratory results showed leucopenia in all cases. Seven cases had thrombocytopenia. Serum aspartate aminotransferase (AST) (median 107 U/L) and alanine aminotransferase (ALT) (median 117 U/L) were elevated in all cases. Lactate dehydrogenase (median 636 U/L) and creatine phosphokinase (median 266 U/L) levels were elevated in six and four cases, respectively. Diagnosis was reached by ELISA method for C-CHF in four cases. The serum samples were positive by both ELISA and PCR in three cases and only by PCR in one case. All cases were treated with oral ribavirin and supportive therapy and discharged with cure.