Malaria is the world's most important parasitic infection. Malaria may rapidly progress to complications and death without prompt and appropiate treatment. In this study; epidemiological, clinical, diagnostic, therapeutic and prognostic features of 22 patients (4 female, 18 male, mean age: 36.7±3.59, range: 18-75) admitted to the Department of Microbiology and Infectious Diseases, School of Medicine, Uludağ University, Bursa, Türkiye, between January 1987 and May 2005 were retrospectively evaluated. The diagnosis was confirmed by microscopy of Giemsa stained thin blood films in all cases, at a magnification of 1000. Plasmodium vivax was the most commonly identified species (18 local and 1 foreign), followed by Plasmodium falciparum (3 foreign). The most of the patients (36.3%) was over 40 years of age. The 27.2% of cases acquired the disease in southeastern Anatolian region where malaria is endemic. Presenting symptoms included fever (100%), chills (63.6%), malaise (34.8%) and sweats (31.8%). The physical examination of the cases showed hepatomegaly (45.4%), splenomegaly (31.8%) and hepatosplenomegaly (34.3%). The rise in erythrocyte sedimentation rate was the most frequent laboratory abnormality (86.3% of cases), followed by thrombocytopenia (55%). Chloroquine+primaquine were given to all patients with P. vivax and one patient with P. falciparum infection. Chloroquine, primaquine, quinine, doxycycline, fansidar were given to one patient with P. falciparum infection. One patient with P. falciparum infection received chloroquine, doxycycline and mefloquine.