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2003, Cilt 17, Sayı 3, Sayfa(lar) 325-328
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VIVO AND IN VITRO EFFECT OF CLARITHROMYCIN ON TOXOPLASMA GONDII
Hande DAĞCI1, Çiler AKISÜ2, Ahmet ÜNER1, Ümit AKSOY2, Şebnem ÜSTÜN3
1Department of Parasitology, Faculty of Medicine, Ege University; Izmir
2Department of Parasitology, Faculty of Medicine, Dokuz Eylül University; Izmir
3Section of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Ege University; Izmir
Keywords: Toxoplasma gondii, clarithromycin, in vivo susceptibility, in vitro susceptibility, experimental infection, tissue culture
Abstract
In recent years a number of studies have been carried out on the treatment of toxoplasmosis with semi-synthetic macrolides. The purpose of this study was to determine the in vivo and in vitro effect of clarithromycin, a semi-synthetic macrolide, on Toxoplasma gondii. For in vivo study, different doses of clarithromycin were administered intraperitonally by gavage to mice infected with T. gondii. It was observed that the best result was achieved with the application of 300 mg/kg clarithromycin by gavage per day as compared with other doses (Mann Whitney U test, p< 0.05). Different doses of clarithromycin were added onto monolayer HEP-2 cells infected with T. gondii. Fifty mg/L clarithromycin was determined to be more effective that the other doses (Mann Whitney U test, p< 0.05). According to in vivo and in vitro trial results, clarithromycin was found to inhibit the growth of T. gondii.
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