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2002, Cilt 16, Sayı 2, Sayfa(lar) 141-145
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COMPARISON OF HEPATITIS B VIRUS (HBV) SEROLOGICAL MARKERS AND EXISTENCE OF HBV DNA
Mustafa ALTINDİŞ
Afyon Kocatepe Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Afyon
Keywords: Hepatitis B Virus (HBV), HBV DNA, HBsAg, HBeAg, antiHBe

Hepatitis B Virus (HBV) exists commonly all over the world and causes chronic hepatitis, cirrhosis and hepatocellular carcinoma. For this reason, early diagnosis and proper treatment of the infection are of almost importance. Existence of HBV DNA is proven by means of molecular diagnostic methods. The aim of this study was co-assessment of HBsAg and antiHBc total positivity and existence of HBV DNA. Totally 155 serum samples were screened for the presence of HBV DNA with Hybrid Capture method and for hepatitis markers with Microenzyme Immune Assay. HBV DNA was positive in 20 % of 110 HBsAg positive and in 4.4 % of 45 HBsAg negative serum samples. HBV DNA was +/- in 15.9 % of 110 HBsAg positive and in 8.8 % of 45 HBsAg negative serum samples. HBV DNA was positive in 62.5 % of 24 serum samples which were HBeAg positive and antiHBe negative, 5.5 % of 72 which were HbeAg negative and antiHBe positive, 40.0 % of five which were both HBeAg and antiHBe positive, 11.1 % which were negative for both. The positivity rate and the median of HBV DNA of HBeAg positive and antiHBe negative group were significantly higher than the HBeAg negative and antiHBe positive group. Among 40 serum samples which were negative for the serological indicators of HBV exposure (HBsAg, antiHBs, antiHBc), HBV DNA was not positive while HBV DNA was +/- in 12.0 %. HBV DNA positivity in antiHBs positive, only antiHBe and antiHBc positive and isolated antiHBc positive groups were, respectively, 0.0 %, 25.0 % and 10.0 %. According to the results of this study; detection of HBV DNA in serum is directly correlated with HBeAg seropositivity and for the evaluation of HBV DNA results lower than 10 pg/ml, monitorization of cases and more sensitive tests are necessary.

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