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2002, Cilt 16, Sayı 2, Sayfa(lar) 151-157
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THE INVESTIGATION OF TT VIRUS IN CASES SUSPECTED CLINICALLY OF POST TRANSFUSION HEPATITIS WITH UNKNOWN ETIOLOGY
Bekir KOCAZEYBEK
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul
Keywords: TT Virus (TTV), TTV-DNA, hepatitis, transfusion, prevalence, polymerase chain reaction (PCR)

The purpose of this study was to determine the prevalence of TT Virus (TTV) in patients suspected of post-transfusion hepatitis of unknown etiology. TT Virus DNA was investigated in the serum samples of 90 cases who were considered as hepatitis 3-17 weeks after open heart surgery and were shown as negative for TTV DNA before the operation. Cases who were found positive were followed up for TTV DNA for 24 months. TT Virus DNA was investigated with polymerase chain reaction (PCR) method suggested by Takahashi et al. TT Virus DNA was found positive in 21 (23.3%) of the patient group and four (4.4%) of the control group. In the patients detected as TTV DNA positive, the admission time following transfusion was minimum three, maximum 15 and average seven weeks. The ALT levels detected at the time of the admission did not show difference between TTV DNA positive and negative cases. However, ALT levels had a tendancy to rise and reached the highest point nine weeks after the transfusion in TTV DNA positive cases except in two cases and ALT levels attained the normal value after the 13th week except in one case. During the 24 months follow up of the TTV DNA positiveness, it was found as positive at the end of this period in all cases except in one. The results of this study were parallel to the literature suggesting that TTV-DNA except main viral agents known as PTH agent is found in alternating transfused PTH or non-transfused asymptomatic cases. In order to define the epidemiological properties and hepatic-extrahepatic pathologies related to the viral agent more clearly which is probably taken by both transfusion and non-transfusion ways, it is indicated that new clinical studies on transfused but non-PTH patients are needed.

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