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2002, Cilt 16, Sayı 2, Sayfa(lar) 179-182
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THE INVESTIGATION OF RESISTANCE RATIOS OF PSEUDOMONAS AERUGINOSA ISOLATES TO VARIOUS ANTIMICROBIALS
Onur ÖZGENÇ, Ayten URBARLI, Mine ERDENİZMENLİ, Nilgün FİDAN, Alpay ARI
SSK İzmir Eğitim Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir
Keywords: Pseudomonas aeruginosa, in vitro antibiotic resistance, disk diffusion method

Pseudomonas aeruginosa has caused an important resistance problem in SSK Izmir Teaching Hospital. The susceptibilities of 199 P. aeruginosa strains, which were isolated from clinical specimens sent to the clinical microbiology laboratory from hospitalized patients or out-patient clinics in 1996 as colonizing bacteria or clinical pathogens, to various antimicrobials were investigated by using disk diffusion method following NCCLS standards. The resistance ratios (%) of P. aeruginosa strains to various antimicrobials were as follows: Amoxicillin-clavulanate 100, ceftazidime 23, cefotaxime 81, aztreonam 44, imipenem 18, meropenem 17, gentamicin 64, netilmicin 42, amikacin 27, tobramycin 57, ciprofloxacin 40, ofloxacin 55 and norfloxacin 30. In intensive care unit these resistance ratios were found highly elevated, and especially it was pointed out that P. aeruginosa isolates showed important resistance problems to aminoglycosides, quinolones, and even to carbapenems. Among oximino-beta lactams, the lowest resistance ratio of the total strains was found to ceftazidime (23%). It is known that although these strains are found to be susceptible to third generation cephalosporins and aztreonam, those antimicrobials should be used under control for the treatment of P. aeruginosa infections because of their inducible beta-lactamase activities. It can be concluded that determining the resistance patterns and antibiotic using policies every year is very important for the infection control of hospitals.

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