The diagnosis of Lyme disease is based primarily on the presence of a characteristic clinical picture, exposure in an endemic area, and an elevated antibody response to Borrelia burgdorferi. In serologic testing for Lyme disease, ELISA- positive specimens should be confirmed with Western blotting. In this article, a 34-year-old female patient with Lyme meningitis is presented. She had clinically typical finding of meningoencephalitis. The diagnosis was confirmed with serological tests, namely, ELISA and Western blotting. She recovered completely with doxycycline therapy.