Kaposi's sarcoma was the first cancer to be recognised as related to the Acquired Immunodeficiency Syndrome (AIDS) and was designated as such by the Centers for Disease Control. Kaposi's sarcoma is a multifocal neoplasm, and skin and oral cavity are the most common sites of presentation of this neoplasm in HIV infected patients. The involvement of organs and lymph nodes are also seen. In this paper, two male AIDS patients, aged 37 and 26, with Kaposi's sarcoma with diffuse visceral involvement are presented.