2003, Cilt 17, Sayı 3, Sayfa(lar) 321-324 |
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AN INVESTIGATION ON THE ANTIFUNGAL SUSCEPTIBILITY AND PHOSPHOLIPASE ACTIVITY OF CANDIDA SPECIES |
Sema KEÇELİ1, Fatma BUDAK1, Gülden SÖNMEZ TAMER1, Ayşe WILLKE2 |
1Kocaeli Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İzmit / Kocaeli 2Kocaeli Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, İzmit / Kocaeli |
Keywords: Candida species, in vitro antifungal susceptibility, phospholipase activity, E test |
The purpose of this study was to identify Candida spp., to determine the in vitro antifungal susceptibility and to investigate the relationship between susceptibility and phospholipase activity. The in vitro antifungal susceptibility o 73 Candida spp. isolated from different clinical specimens were determined by using E test. Distribution of isolates were C. albicans (56), C. tropicalis (nine), C. kefyr (three), C. guilliermondii (two), C. krusei (one), C. glabrata (one), and C. famata (one). The highest rate of resistance was against itraconazole; resistance was found in seven C. albicans, two C. guilliermondii, two C. tropicalis and one C. krusei strain(s). Resistance to fluconazole was in nine isolates (six C. albicans, two C. tropicalis, one C. krusei). No resistance against amphotericin B was detected. Phospholipase activity was detected in 50 (45 C. albicans and five non-C. albicans) isolates. There was no statistical relationship between phospholipase activity and azole resistance (p>0.05). In conclusion; the identification of Candida spp. and determination of antifungal MIC levels are important in regard to the management of treatment. Azole resistance is not related to phospholipase activity, one of the major virulence factors of C. albicans.
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