Hepatitis B Virus (HBV) is suggested to show its effects via immunological alterations, not by direct cytopathic damage. Patients who fail to mount a vigorous immune response in acute HBV develop chronic infection. The aim of this study was to determine serum immunoglobulin levels and oxidative burst capacity of neutrophils in patients with chronic hepatitis B carriers. The study groups were composed as follows: Anti-Hbe (+) group: 20 patients with HBsAg (+), anti-HBe (+) and anti-HBc IgG (+); HBeAg (+) group: 10 patients with HbsAg (+), HbeAg (+) and anti-HbcIgG (+). The control group was composed of age and sex-matched 30 healthy people naturally immunized against HBV who were negative for HBsAg and positive for anti-HBs and anti-HBc IgG. Sera of the study group were investigated for IgG, IgA, IgM, and IgG subclasses (IgG₁, IgG₂, IgG₃, IgG₄). Oxidative capacity of neutrophils were investigated by flowcytometric neutrophil burst test. Serum immunoglobulin (IgG, IgA, IgM) levels were not significantly different between three groups (p>0.05). When IgG₁, IgG₂, IgG₃ and IgG₄ levels were compared, the relation between anti-HBe (+) and HBeAg (+) patients were insignificant, but when these two groups were compared with the control group, anti-Hbe (+) patients had significantly higher IgG1 and IgG₂ levels while HBeAg (+) patients had only significantly higher IgG₂ levels. Flowcytometric neutrophil burst test values were significantly lower in HBeAg (+) patients when compared with anti-HBe (+) patients and the control group. Immunological responses are important in the development and progression of chronic hepatitis B infection. Further investigations on neutrophil functions may lead to new treatment modalities and may be useful to understand the survey of the disease.