Infrequent involvement sites of brucellosis may cause a wide range of nonspecific symptoms. In this paper, a 60-year-old female case with nervous system, gastrointestinal tract and soft tissue involvement of brucellosis is presented. It is one of the rare cases in literature with ventriculoperitoneal shunt infection and the first case with subcutaneous abscess in the incision site due to brucellosis. Also it shows that brucellosis should be considered in the differential diagnosis for acute abdomen in endemic regions.