Endocarditis and pancreatitis are rare complications of brucellosis. In this paper, a 52-year-old male case of Brucella abortus endocarditis presenting with acute pancreatitis is presented. The diagnosis was made by clinical features, positive blood cultures, positive serology, vegetation on the aortic valve, high serum amylase and lipase level. Specific antimicrobial treatment for brucellosis was started and a surgical operation was planned; but the patient developed severe cardiac failure and died on the fifteenth day of his admission.