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2005, Cilt 19, Sayı 4, Sayfa(lar) 415-418
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ADENOSINE DEAMINASE ACTIVITY IN CEREBROSPINAL FLUID IN TUBERCULOUS MENINGITIS
Bahar ÖRMEN1, Murat ÖRMEN2, Nesrin TÜRKER1, Nejat Ali COŞKUN1, Banu ÖNVURAL2, Figen KAPTAN1, Sibel EL1, Serap URAL1, İlknur VARDAR1
1İzmir Atatürk Eğitim ve Araştırma Hastanesi İnfeksiyon Hastalıkları Kliniği, İzmir
2Dokuz Eylül Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, İzmir
Keywords: Tuberculous meningitis, adenosine deaminase, cerebrospinal fluid, diagnosis

Tuberculous meningitis is the most severe form of tuberculosis. Because of high morbidity and mortality rates, early diagnosis and treatment are very important. For diagnosis of tuberculous meningitis there is requirement for rapid laboratory tests with high sensitivity. For this purpose, in this study the contribution of cerebrospinal fluid (CSF) Adenosine Deaminase (ADA) activity measurement to the diagnosis of tuberculous meningitis was evaluated. Twenty suspected tuberculous meningitis cases and 20 control cases were taken into the study. Cerebrospinal fluid ADA measurements were 16.02 + 10.95 U/L and 2.30 + 1.27 U/L in these two groups, respectively. In the suspected tuberculous meningitis group CSF ADA activity was significantly higher than the control group (p= 0.000). Specifity and sensitivity of the CSF ADA levels were calculated for different cut-off values. As conclusion, measurement of CSF ADA activity was found to be helpful in the diagnosis of tuberculous meningitis.

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