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2006, Cilt 20, Sayı 2, Sayfa(lar) 111-116
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IN VITRO ANTIBIOTIC SUSCEPTIBILITY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM NORMALLY STERILE SPECIMENS: EVALUATION OF 5-YEAR RESULTS
Hüsnü PULLUKÇU1, Şöhret AYDEMİR2, Ajda TURHAN2, Alper TÜNGER2, Mehmet Ali ÖZİNEL2, Sercan ULUSOY1
1Ege Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İzmir
2Ege Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İzmir
Keywords: Pseudomonas aeruginosa, nosocomial bacteremia, antibiotic resistance

The treatment of Pseudomonas aeruginosa infections, especially of the nosocomial ones, is extremely difficult because of the resistance of this bacteria against many of the commonly used antibiotics. The mortality and morbidity rates of P. aeruginosa bacteremia are higher than those caused by other gram-negative bacteria. The ampirical treatment should be started immediately in case of a suspected P. aeruginosa infection. Regional resistance rates should be known for the empirical treatment. The aim of this study is to evaluate the resistance state of the P. aeruginosa strains isolated from blood and cerebrospinal fluid cultures of the patients hospitalized in Ege University Hospital, against antipseudomonal antibiotics in a five year time interval and also to overview empirical treatment options. The resistance state of 421 P. aeruginosa strains, as cause of infection, against antipseudomonal antibiotics was evaluated with disc diffusion method and evaluated according to years. When the resistance rates were considered, the resistance against netilmycin, ceftazidime and piperacilline/tazobactam was increased in 2004 compared with preceeding two years (not significant, p>0.05). The resistance against amikacin was decreased although it was used commonly. The resistance rates against other groups of antibiotics changed according to years. As a result, regional resistance rates should be known for empirical treatment in case of life threatening P. aeruginosa infections.

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